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Presents a detailed discussion of important solid–state properties, methods, and applications of solid–state analysis
The study on solid–state properties of pharmaceutical materials, including drug substances and excipients, is essential for pharmaceutical research and development involving solid dosage forms. Solid characteristics such as polymorphism, formation of hydrates and solvates, degree of crystallinity, and mechanical properties have profound effects on the quality of drug substances and drug products through their effects on properties such as solubility, dissolution, bioavailability, processability, and stability. A fundamental knowledge of solid–state properties is therefore critical for the design, formulation, and manufacture of numerous drug substances and products.
Solid–State Properties of Pharmaceutical Materials presents a detailed discussion of important solid–state properties, and methods of solid–state analysis. The text is split into four parts which includes physical forms of pharmaceutical solids, methods of analysis, critical properties of pharmaceutical solids, and important applications of physical characterization. The methods covered within these parts will allow the reader to design, formulate, and manufacture desirable solid forms for drugs.
Solid–State Properties of Pharmaceutical Materials features:
- An introduction to solid–state pharmaceuticals such as amorphous form, mesophase, polymorph, hydrate/solvate, salt, co–crystal, nano–particles, and solid dispersion
- Intensive discussions about characterization techniques such X–ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid–state NMR
- Rigorous reviews of quality attributes of pharmaceutical solids such as particle size/surface area, water sorption, dissolution, solubility, mechanical properties, physical stability, and chemical stability
- A thorough presentation about applications of physical characterization techniques in developing and testing drug substances and drug products such as form selection, mixture analysis, formulation development, and quality by design
Solid–State Properties of Pharmaceutical Materials provides a profound knowledge base to readers to help them understand pharmaceutical solids, and offers analytical tool kits for problem solving related to drug substances and drug products.
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